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Poorly differentiated thyroid carcinoma (PDTC) is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.
Video Poorly differentiated thyroid cancer
Histopathological features
- Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
- Round or oval nests (insulae) or in trabeculae.
- Solid growth and presence of microfollicles, some of which contain dense colloid.
- Extrathyroidal extension and blood vessel invasion
- Foci of necrosis,
- Larger than 5 cm in greatest diameter at diagnosis
Maps Poorly differentiated thyroid cancer
Clinical features
- PDTC affects predominantly females about 55 years of age
- Both local and distant (lung, bone, brain)
src: clincancerres.aacrjournals.org
References
Source of the article : Wikipedia
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